Porcine Circovirus Type 1 (PCV1) third viral protein (VP3) has been shown to induce apoptosis in cancer cells. Sequence analysis revealed that PCV1 VP3 contains an N-terminal region homologous to its apoptotic homolog, VP3 of Chicken Anemia Virus, and a C-terminal extended region. This study successfully developed a method to quantitatively assess and identity the region responsible for PCV1 VP3’s apoptotic activity. Our apoptosis studies suggest that the C-terminal region is responsible for the robust apoptosis-inducing property of PCV1 VP3.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Vu, Phuong Thuy
• Filatava, Evgenia Jen

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043015-153412

Advisor

• Heilman, Destin

Year

• 2015

Date created

• 2015-04-30

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright