Faculty Advisor

Ryder, Elizabeth F.

Abstract

PTEN is a novel tumor suppressor gene that is deleted in 70% of glioblastomas. Using rtPCR, western blotting, immunocytochemistry, and immunoprecipitations, we studied the expression of PTEN in rat glioma and pheochromocytoma and human glioblastoma, cell lines. Our results suggest that lack of PTEN protein may be involved in the tumorigenicity of these cell lines.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 1999

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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