Faculty Advisor

Hobey, William D.

Abstract

Rab GTPases regulate vesicle trafficking in the cell and there are 37 functionally distinct members. This project began a molecular cloning library to facilitate a proteome wide quantitative analysis. This is the start of determining which RAB interactions are bona fide, which are not and give an insight into modes specificity. It will propel a structural study of Rab GTPases. This work clarifies a possible interaction between a Rab and an effector and shows the novel crystal structure of Rab33b.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2003

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemistry and Biochemistry

Advisor Program

Chemistry and Biochemistry

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