Faculty Advisor

Ryder, Elizabeth F.

Abstract

Short periods of ischemia have been shown to protect the heart during future, prolonged ischemic episodes. To isolate factors involved in ischemic preconditioning, New Zealand white rabbit hearts were subjected to episodes of ischemia. The rabbit jejunum was used to assay HPLC fractions of heart effluent. Three factors affecting contractile activity were found: Fraction I, a depressive factor identified as adenosine; Fraction 2, a depressive factor thought to be Met-Enkephalin; and Fraction 3, an excitatory factor suspected to be PGE.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2002

Major

Biology

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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