Faculty Advisor

Rulfs, Jill

Abstract

Since prolactin secretion decreases with parity, we investigated estradiol's effects on its secretion. Two groups of age matched rats were ovariectomized, then challenged with 5 or 25 up/kg estrogen. Serum prolactin levels were determined by radioimmunoassay. Prolactin levels in primiparous females increased significantly at 5 ug/kg estradiol. While levels in nulliparous females show a dose responsive change, it was not significant. These findings may indicate an altered sensitivity to estrogen in dopaminergic control of prolactin secretion.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2003

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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