Faculty Advisor

Heilman, Destin

Abstract

Some circoviridae viruses produce proteins that selectively kill cancer cell, yet little is known about the mechanism. Cell cycle and localization studies of cells expressing these proteins reveal phenotypic differences, suggesting that these proteins may induce apoptosis via distinct mechanisms. Prior research has yielded little information regarding said assumption. Our experiments have yielded evidence that suggests apoptin and PCV1-VP3 both interact with APC subunit cdc27, supporting a hypothesis that the mechanism of cell death is conserved, and that the observed differences between cells expressing these proteins are ancillary. This would imply that the extraneous phenotypes need not addressed in the development of a small molecule drug that replicates the effect of these proteins.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemistry and Biochemistry

Available for download on Thursday, April 29, 2021

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