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Cell Culture System to Enable a Therapy for Volumetric Muscle Loss

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Current skeletal muscle cell therapy systems have limited effectiveness due to poor proliferative capability. The cells are not functional enough to be implanted into a critical size muscle defect as a therapy for volumetric muscle loss. Altering in vitro factors, such as mitogens and oxygen tension, can have a favorable effect on the cells ability to retain myogenic potential. Individual system parameters were characterized through experimental testing of culture conditions, media composition, and cell kinetics. Our team designed, engineered, and validated a final scalable cell expansion system for proliferating myogenic cells in vitro.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-050114-114054
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  • 2014
Date created
  • 2014-05-01
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Permanent link to this page: https://digital.wpi.edu/show/4j03d1440