Faculty Advisor

Adams, David S.

Abstract

The data in this MQP show that circadian rhythm and low-level irradiation of hosts affects the success of bone marrow engraftment. The optimal time of bone marrow transplant was determined through the study of circadian rhythm of the donor and host bone marrow. Sub-myeloablation of the host allowed for high levels of engraftment even when low cell doses or 5-FU treated marrow was injected. This in turn eased the data analysis because differences between groups were easier to see. The effects of circadian rhythm need to be looked into further as they offer a route to more effective bone marrow transplants.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 1999

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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