Faculty Advisor

Ryder, Elizabeth F.


The gene mig-10 in C. elegans affects cell migration, axon guidance, and process outgrowth. mig-10 shows sequence homology to signal transduction proteins that interact with the rac GTPases. In order to determine if mig-10 have any interaction with the rac genes, mig-10 double mutants with a number of rac pathway genes were constructed. All double mutants with each rac gene showed a more severe defect in process outgrowth than the single mutant mig-10(ct41), while only some rac gene double mutants had a greater defect in embryonic migration. These results suggest mig-10 interacts with the rac genes.


Worcester Polytechnic Institute

Date Accepted

January 2003


Biology and Biotechnology

Project Type

Major Qualifying Project


Restricted-WPI community only

Advisor Department

Biology and Biotechnology