Faculty Advisor

Billiar, Kristen

Faculty Advisor

Overstrom, Eric W.

Faculty Advisor

Rolle, Marsha W.

Abstract

Cyclic loading is an important stimulus for creating mechanically stable tissue engineered blood vessels. The goal of this work is to create a device that dynamically conditions rings of vascular tissue created by cells in culture without the use of a scaffold. To create a high-throughput and accurate yet inexpensive device, a regulated pressure source and electronic valve controller were utilized to cyclically inflate up to 32 ring segments cultured on a series of silicone tubes encased in standard sterile conical tubes. This device will be used to determine the dynamic culture conditions that optimize engineered vessel growth and maturation in culture.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2009

Major

Mechanical Engineering

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Advisor Department

Biology and Biotechnology

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