Student Work

Design of a Bioreactor to Cyclically Strain Tissue Engineered Blood Vessels

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Cyclic mechanical loading improves strength and extracellular matrix (ECM) synthesis in tissue engineered blood vessels (TEBV). The goal of this project was to design a device to impart cyclic circumferential stretch on cell-derived TEBV rings cultured on flexible silicone tubing. Our device cyclically displaces water (75 uL volume) to inflate tubing at a frequency of 1 Hz. During static inflation tests, the tubing diameter increased by 10+/-1.6%. TEBV rings were loaded onto silicone tubing and subjected to mechanical conditioning for 3-7 days. Our device conditioned samples in an incubator at 10% distension at a frequency of 1 Hz. Static and conditioned tissues remained viable and uncontaminated and exhibited high cell densities and increased thicknesses from 3 to 7 days.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042211-141657
Advisor
Year
  • 2011
Date created
  • 2011-04-22
Resource type
Major
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Last modified
  • 2021-02-02

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Permanent link to this page: https://digital.wpi.edu/show/z603r0156