Faculty Advisor

Ryder, Elizabeth F.

Faculty Advisor

Wobbe, Kristin K.

Abstract

Cytoplasmic adaptor MIG-10 plays a role in neuronal migration and process outgrowth in C. elegans. Data from a yeast-two hybrid assay indicate that MIG-10 interacts with ABI-1, a protein involved in regulation of actin polymerization and required for neuronal migration and outgrowth. To further characterize the interaction between MIG-10 and ABI-1, deletion mutants were created and co-immunoprecipitation assays and western blots were performed. Preliminary results indicate that the C-terminal SH3 region of ABI-1 is required for its interaction with MIG-10.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemistry and Biochemistry

Share

COinS