Zhou, Hong Susan
A lactate biosensor was designed to monitor tumor size in patients with Glioblastoma Multiforme, an aggressive form of brain tumor. Current monitoring methods are expensive and not conducive to frequent use, creating a need for a biosensor to frequently monitor GBM tumor size. This biosensor was composed of polypyrrole (PPY) and polyaniline (PANI) layers with lactate oxidase (LOX) cross-linked to the surface using glutaraldehyde. The components of the biosensor were tested iteratively. The biosensor is able to detect increases in lactate concentration. It is has a higher maximum current than other designs and is able to detect greater presence of lactate. More testing is needed in order to continue validation of the biosensor and extend the technology to other metabolites.
Worcester Polytechnic Institute
Major Qualifying Project
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