Hobey, William D.
The K-C1 cotransport system controls potassium and chloride ion flux across erythrocyte cell membranes. It was previously determined that K-C1 cotransport activation requires the presence of a naphthylene ring in the activating drug. Therefore, this project's purpose was to test the effects of 1,8-naphthylene ring substitutions on flux activation. Acenaphthene and acenaphthylene exhibited the greatest amount of potassium flux; 1-substituted analogs induced moderate flux in the presence of calcium, while other analogs showed no effect. Consequently, a revised binding site model is proposed.
Worcester Polytechnic Institute
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Chemistry and Biochemistry