Faculty Advisor

Adams, David S.

Abstract

The molecular basis for the disease osteopetrosis and its relationship to commonly known diseases of the skeleton like osteoporosis is presented. It is known that colony stimulating factor-1 (CSF-1) can improve osteoclast function and increase their numbers in the tl (toothless) rat model. The technique of differential display was described and used to identify several genes including collagen I (2) which is overexpressed in the mutant tl rat, but not in its CSF-1 treated or normal littermate.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 1999

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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