Adams, David S.
The molecular basis for the disease osteopetrosis and its relationship to commonly known diseases of the skeleton like osteoporosis is presented. It is known that colony stimulating factor-1 (CSF-1) can improve osteoclast function and increase their numbers in the tl (toothless) rat model. The technique of differential display was described and used to identify several genes including collagen I (2) which is overexpressed in the mutant tl rat, but not in its CSF-1 treated or normal littermate.
Worcester Polytechnic Institute
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Biology and Biotechnology