Faculty Advisor

Politz, Samuel M.

Abstract

The nematode Caenorhabditis elegans changes its surface composition during development, such that an L1 surface antigen is turned off at a later larval stages in response to environmental signals. Worms with mutations in gene srf-6 display the L1 antigen at stages L1 through L4 (Constitutive Larval Display or CLD). Osm-3 mutations affect the worm's chemosensation. A mutation in the osm-3 gene was shown to block CLD in srf-6 mutant worms, indicating that osm-3 activity is required for srf-6 to have its effect.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2005

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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