Adams, David S.
UMass Medical School
The objective of this project was to determine if the antioxidant, -lipoic acid (LA), inhibits oxalate (OX) toxicity, via free radical production, on renal systems. The cell line, LLC-PK, was used as a model to observe this phenomenon in kidney cells. LA was found to have no effect preventing OX-induced damage at the dosages tested. The implications of this study should encourage further studies of novel drugs which may have the property of reducing oxidative damage to renal systems.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology