Faculty Advisor

Dittami, James P.

Abstract

The primary goal of this project is to explore the synthesis of huperzine alkaloids via the photoinitiated intramolecular ylide alkene cylcloaddition. Huperzine A and B are both potent inhibitors of acetylcholinesterase, the enzyme responsible for the degradation of acetylcholine. Thus improved synthetic approaches to huperzine A and B could prove useful in developing new therapies for diseases which are manifested by low acetylcholine levels.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2000

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemistry and Biochemistry

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