Dittami, James P.
The primary goal of this project is to explore the synthesis of huperzine alkaloids via the photoinitiated intramolecular ylide alkene cylcloaddition. Huperzine A and B are both potent inhibitors of acetylcholinesterase, the enzyme responsible for the degradation of acetylcholine. Thus improved synthetic approaches to huperzine A and B could prove useful in developing new therapies for diseases which are manifested by low acetylcholine levels.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry