Adams, David S.
The purpose of this project was to determine if the dopaminergic cells of the substantia nigra degenerate by apoptosis in an MPTP mouse model of Parkinson's disease. Methods to identify DNA fragmentation, chromatin condensation, formation of apoptotic bodies and caspase-3 activation accurately detected apoptosis in an X-57 cell system. Preliminary results on brain sections of MPTP treated mice suggest that apoptosis is occurring. This research was performed in the laboratory of Dr. Neil Aronin at UMass Medical School.
Worcester Polytechnic Institute
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Biology and Biotechnology