Faculty Advisor

Hobey, William D.

Abstract

The role of MLCK in propranolol activated flux of potassium ions in red blood cells was monitored via a computerized method using ion selective electrodes. An inhibitor specific to MLCK, ML-7, was introduced to a suspension of cells, and propranolol was added. Potassium concentrations were taken for 100 minutes. After treatments of different concentrations of ML-7, inhibition was seen via a decrease in the observed PK values. This discovery leads to the further characterization of the role of MLCK in the proposed mechanism of propranolol activated potassium flux.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2005

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemistry and Biochemistry

Advisor Program

Chemistry and Biochemistry

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