Faculty Advisor

Heilman, Destin

Abstract

The selective cancer killing properties of the homologous viral proteins apoptin and PCV1-VP3 may help reveal a novel target mechanism for cancer treatment. A difference between the two proteins is the subcellular localization behavior. It has been suggested that the cell-type specific nucleocytoplasmic shuttling of apoptin plays a role in selective induction of apoptosis by driving the protein into the nucleus of transformed cells. However, PCV1-VP3 does not display selective localization behavior, and remains in the cytoplasm while still causing cell death exclusively in cancer cells. This study employs both truncation and point mutants constructs to assess the functionality of nuclear export signal sequences predicted from the sequence of PCV1-VP3.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemistry and Biochemistry

Advisor Program

Chemistry and Biochemistry

Available for download on Thursday, April 29, 2021

Your accessibility may vary due to other restrictions.

Share

COinS