Faculty Advisor
Adams, David S.
Sponsor
UMass Medical School
Abstract
The SNARE complex, involved in vesicular trafficking and exocytosis, is composed of proteins in the vesicular membrane (V-SNAREs) that intertwine with proteins of the target membrane (T-SNAREs). Our results show that modified bovine neurosecretory granules (NSG) were able to spontaneously fuse with a planar lipid membrane, containing the t-SNARE syntaxin 1A. This provides evidence that syntaxin alone is able to form a functional fusion complex. This project is another step towards producing an artificial synapse to study possible regulatory components affecting vesicle fusion.
Publisher
Worcester Polytechnic Institute
Date Accepted
January 2000
Major
Biotechnology
Project Type
Major Qualifying Project
Copyright Statement
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Accessibility
Restricted-WPI community only
Advisor Department
Biology and Biotechnology
Advisor Program
Biology and Biotechnology