Student Work

The role of Cathepsin L in the innate immune system

Public

Downloadable Content

open in viewer

Differences in innate immune response to L. Monocytogenes infection are associated with genetic polymorphisms, and are studied using inbred mouse strains. Differences in susceptibility in BALB/c and C57BL/6J strains have been associated with the L2 locus of chromosome 13. Cathepsin L, which is located within this locus, was identified as a candidate susceptibility gene based on its differential expression in macrophages from these mice. A construct was created to analyze cathepsin L expression in macrophages. A novel mechanism of Ctsl regulation was discovered, which appeared to be controlled at a transcriptional level based on introduction of dsDNA or LPS. There were differences in this regulation pathway between the two mouse strains.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042711-101639
Advisor
Year
  • 2011
Sponsor
Date created
  • 2011-04-27
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/bz60cx82v