Student Work

Design of a High-Throughput Molecular Diffusion Device to Study Molecular Transport through Collagen Membranes

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Diffusion studies allow scientists to gain a better understanding of the function and structure of membranes. However, these diffusion studies can be time consuming and costly when using current devices on the market. Our goal was to design and validate an affordable high-throughput molecular diffusion system to characterize membranes. Our device was validated using glucose, bovine serum albumin (BSA), and gamma globulin. The calculated coefficients were 5.58x10^-6 cm^2/s, 7.08x10^-8 cm^2/s, and 4.83x10^-8 cm^2/s for glucose, BSA, and gamma globulin, respectively. Diffusion coefficients were shown to be the same for our device and a marketed device and are comparable to published values, suggesting that our device will serve as a facile tool to rapidly characterize engineered membranes.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-042507-233801
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Year
  • 2007
Date created
  • 2007-04-25
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Major
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Last modified
  • 2023-09-19

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Permanent link to this page: https://digital.wpi.edu/show/05741t321