The viral protein PCV1-VP3 is of key interest in the field of cancer therapeutic development. PCV1-VP3 exhibits cancer-specific apoptotic capabilities in p53-null cancer cells, but not in human primary cells. PCV1-VP3 was discovered to exhibit subcellular localization to the cytoplasm of transformed cells in a manner that is independent of CRM1 nuclear export. It was also revealed that two regions of the protein exhibit differential localization capabilities when separated, which raises further questions regarding the functional capabilities of each region with respect to cancer "sensing" and apoptosis induction.
Worcester Polytechnic Institute
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Chemistry and Biochemistry
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