Faculty Advisor

Ruiz, Carolina

Faculty Advisor

Ryder, Elizabeth F.

Abstract

This project created a computational biology tool to discover regulatory regions in DNA and their influence on gene expression. First, motifs in the C. elegans genome were found using an expectation maximization algorithm. Then association rules were mined to correlate the presence of motifs with cell-type expressions. A software system, CAGE, was created to perform this process. CAGE generated various types of models that pinpoint the biological significance of the motifs. The predictive accuracy of the models was assessed.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2002

Major

Biotechnology

Major

Biology and Biotechnology

Major

Computer Science

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Computer Science

Advisor Department

Biology and Biotechnology

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