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Amphetamine Induced Dopamine Transporter Internalization: A Structure/Function Study

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Dopamine is a neurotransmitter that plays a key role in locomotion and mood, and an imbalance of dopamine levels has found to play a significant role in Schizophrenia, ADHD, and Parkinson’s disease. Dopamine is released into the neuronal synapse and taken in by dopamine transporters, which constituently trafficking in and out of the plasma membrane. Using chimeric dopamine/serotonin transporters, this research was aimed at determining the protein sequences necessary for the dopamine transporter trafficking in response to amphetamine. It was shown that amphetamine causes a decrease in dopamine transporter cell surface density and an increase in serotonin transporters. Newly designed dopamine transporter chimeras were made to be used in future experiments.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042113-220656
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  • 2013
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Date created
  • 2013-04-21
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