Faculty Advisor

Dempski, Robert E.

Center

UMMC / University of Massachusetts Medical Center

Abstract

Dopamine is a neurotransmitter that plays a key role in locomotion and mood, and an imbalance of dopamine levels has found to play a significant role in Schizophrenia, ADHD, and Parkinson’s disease. Dopamine is released into the neuronal synapse and taken in by dopamine transporters, which constituently trafficking in and out of the plasma membrane. Using chimeric dopamine/serotonin transporters, this research was aimed at determining the protein sequences necessary for the dopamine transporter trafficking in response to amphetamine. It was shown that amphetamine causes a decrease in dopamine transporter cell surface density and an increase in serotonin transporters. Newly designed dopamine transporter chimeras were made to be used in future experiments.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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