Faculty Advisor

Ruiz, Carolina

Faculty Advisor

Ryder, Elizabeth F.

Abstract

This project developed a computational biology tool that discovers regulatory regions in DNA and their impact on gene expression. The MAGE computer system, utilizing three software components, predicts gene expression in cells. Motifs or patterns in the promoter regions, from both the C. elegans and C. briggsae genomes, were found using the expectation maximization and Gibbs algorithms. These motifs were mined and used to build association rules models that predict cell specific expression. The accuracy of various models was assessed.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2003

Major

Biotechnology

Major

Biology and Biotechnology

Major

Computer Science

Major

Electrical and Computer Engineering

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Computer Science

Advisor Department

Biology and Biotechnology

Advisor Program

Computer Science

Advisor Program

Biology and Biotechnology

Share

COinS