Faculty Advisor

Gaudette, Glenn R.

Abstract

Drug screening is an expensive process. Due to the limitations of preclinical testing, most drugs fail during clinical trials. No system currently available can determine a drug’s effect on each organ in relation to one another. This project presents the novel use of decellularized leaves seeded with human cells connected on the same recirculating perfusion system for drug screening purposes. In our system, each leaf is seeded with a different cell type. By interconnecting these leaves, we can study cell interactions for drug screening purposes. Testing has shown that our system can successfully decellularize spinach leaves, and human cells can be successfully seeded onto the surface of these leaves.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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