Faculty Advisor

Gaudette, Glenn R.

Abstract

Drug-induced cardiotoxicity remains a primary reason why new pharmaceutical compounds are withdrawn from clinical trials and the consumer market. We have developed a novel cardiotoxicity screening device that utilizes cardiomyocytes seeded on fibrin microthreads to form a three-dimensional model for cardiac tissue. Our device can be used to analyze the contractile properties of these seeded threads. Upon the addition of pharmaceutical agents, the device has the potential to detect changes in contraction and thus identify cardiotoxic compounds.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2014

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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