Faculty Advisor

Adams, David S.

Abstract

This project examined the mechanisms responsible for the inhibition of beta-amyloid production by protease inhibitors in a whole cell model. Dose-dependency curves were created for eight potent protease inhibitors and the inhibition patterns for both A1-40 and A1-42 were studied. Results indicated that a single -secretase was responsible for the cleavage of A and the project revealed eight potential leads in the AstraZeneca drug screening project.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2000

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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