Argüello, José M.
This project investigated the function and mechanism of actin and myosin II related cytokinesis in normal rat kidney cells. Cytokinetic inhibitory drugs such as Blebbistatin and Cytochalasin D were used to study the origin of midzone microtubules and the global effects of cleavage failure in dividing cells. Micromanipulation experiments were done to test local effects of such drugs on equatorial and polar cortices of the cell. Results indicated the significant role of myosin II in the polar region that contributes to cleavage furrow.
Worcester Polytechnic Institute
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Chemistry and Biochemistry