Faculty Advisor

Argüello, José M.

Abstract

This project investigated the function and mechanism of actin and myosin II related cytokinesis in normal rat kidney cells. Cytokinetic inhibitory drugs such as Blebbistatin and Cytochalasin D were used to study the origin of midzone microtubules and the global effects of cleavage failure in dividing cells. Micromanipulation experiments were done to test local effects of such drugs on equatorial and polar cortices of the cell. Results indicated the significant role of myosin II in the polar region that contributes to cleavage furrow.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2003

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemistry and Biochemistry

Advisor Program

Chemistry and Biochemistry

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