Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Faculty Advisor

Ryder, Elizabeth F

Abstract

During development in Caenorhabditis elegans (C.elegans), several neurons migrate to specific locations, within the body; this is important in the formation of the nervous system. Mutations in the mig-10 gene have been phenotypically identified by incomplete migration of those cells and the truncation of the excretory cell. This project focuses on identification of additional mutations in the gene, isolated by non-complementation screening, and characterized using PCR and restriction digestion. Missense mutations may identify functional domains in the MIG-10 protein.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

BC

Advisor Department

BIO

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