Faculty Advisor

Ryder, Elizabeth F.

Abstract

During nervous system development, the cytoplasmic signaling protein MIG-10 activates cellular processes in response to guidance cues which ultimately lead to axonal growth and migration. Interactions between MIG-10 and two candidate downstream proteins, CSN-5 and ARX-3, were studied in vivo, using mutant transgenic C. elegans strains, and in vitro, using a co-immunoprecipitation system. Preliminary results indicate interaction in vitro between MIG-10 and both proteins. In vivo experiments are ongoing.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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