Faculty Advisor

Ryder, Elizabeth F.

Abstract

During the development of C. elegans, neurons migrate to specific locations in the worm through the actions of various proteins; one protein known to be involved in neuronal migration is MIG-10. As part of an ongoing effort to better understand other proteins involved in the process of neuronal migration, CSN-5, a protein involved in proteosome activity and found to associate with MIG-10, was knocked down using both feeding RNAi and through the creation of a transgenic C. elegans line that produced dsRNA. No effect was measured in the migration of the neurons; however, a conclusion was not reached on the effect of CSN-5 on neuronal migration, because no effect was seen in the MIG-10 controls. The lack of effect may be due to the promoter used.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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