Ryder, Elizabeth F.
This study examined neurological changes associated with gender differences in an animal model of depression. Depression was induced in eighteen Sprague Dawley rats through chronic administration of corticotropin-releasing factor. Several behavioral paradigms were assessed, including tests for cognition, anxiety, and fear. Functional magnetic resonance imaging of responses to a fear inducing predator odor were then carried out. The study found different patterns in brain activation among experimental groups in the hypothalamus, amygdala, and perirhinal cortex.
Worcester Polytechnic Institute
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Biology and Biotechnology