Faculty Advisor

Ryder, Elizabeth F.

Abstract

This study examined neurological changes associated with gender differences in an animal model of depression. Depression was induced in eighteen Sprague Dawley rats through chronic administration of corticotropin-releasing factor. Several behavioral paradigms were assessed, including tests for cognition, anxiety, and fear. Functional magnetic resonance imaging of responses to a fear inducing predator odor were then carried out. The study found different patterns in brain activation among experimental groups in the hypothalamus, amygdala, and perirhinal cortex.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2002

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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