Faculty Advisor

Bagshaw, Joseph C.

Faculty Advisor

Cheetham, Ronald D.

Abstract

This study, sponsored by the University of Massachusetts Medical School, examined the relationship between progesterone and gestational hypertension in spontaneously hypertensive heart failure (SHHF) rats. Blood pressure, water consumption, and blood and urine analyses displayed differences between SHHF and normotensive Wistar-Kyoto (WKY) rats. SHHF rats exhibited higher levels of progesterone receptor A in the kidney and lower levels of serum progesterone compared to WKY rats. These differences were associated with the onset of hypertension in pregnant SHHF rats, possibly playing a role in the disease.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2003

Major

Biology

Major

Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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