Bagshaw, Joseph C.
Cheetham, Ronald D.
University of Massachusetts Medical School
This study, sponsored by the University of Massachusetts Medical School, examined the relationship between progesterone and gestational hypertension in spontaneously hypertensive heart failure (SHHF) rats. Blood pressure, water consumption, and blood and urine analyses displayed differences between SHHF and normotensive Wistar-Kyoto (WKY) rats. SHHF rats exhibited higher levels of progesterone receptor A in the kidney and lower levels of serum progesterone compared to WKY rats. These differences were associated with the onset of hypertension in pregnant SHHF rats, possibly playing a role in the disease.
Worcester Polytechnic Institute
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Biology and Biotechnology