Student Work

A Simple Model for Analyzing Stem Cell Niches in Human Skin

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Each year, millions of Americans require skin grafts. One promising approach is to use patient-derived epithelial stem cells to replace damaged skin. Micro-niches, which support epithelial stem cells, exist within the epidermis. To understand and bio-engineer these niches, a simple experimental platform must be developed. Using an existing basal lamina analogue that mimicked the topography of the dermal-epidermal junction I have developed an approach using optical sectioning fluorescent microscopy that allows for rapid characterization of functional perturbations to this system.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042611-170922
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  • 2011
Date created
  • 2011-04-26
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