Faculty Advisor

Duffy, Joseph B.

Abstract

Each year, millions of Americans require skin grafts. One promising approach is to use patient-derived epithelial stem cells to replace damaged skin. Micro-niches, which support epithelial stem cells, exist within the epidermis. To understand and bio-engineer these niches, a simple experimental platform must be developed. Using an existing basal lamina analogue that mimicked the topography of the dermal-epidermal junction I have developed an approach using optical sectioning fluorescent microscopy that allows for rapid characterization of functional perturbations to this system.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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