Faculty Advisor

Adams, David S.

Abstract

Two HIV-1 clones that have different cytopathogenicity were previously isolated from a single patient. In this MQP PCR amplification of the env, gag, nef, and vpr regions of the two clones was performed. Sequencing of the two clones was done to identify sequence variations potentially responsible for the difference in cytopathogenicity. The vpr sequence of the noncytopathic clone revealed an early stop codon resulting in a truncated protein. This is a significant difference and is a likely candidate for affecting the cytopathogenicity.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 1999

Major

Biology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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