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Library MosSCI: A New Approach to Multiplexed Transgenic Strain Generation

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Early embryogenesis cell fate specification in Caenorhabditis elegans is driven primarily by post-transcriptional regulation, in which RNA-binding proteins bind to the 3' UTRs of complementary mRNAs. POS-1 is a RNA-binding protein necessary for germline specification in early embryogenesis. Transgenic worm strains with possible POS-1 binding sites were used to study the underlying mechanisms of stem cell fate regulation by POS-1. We also modified the Mos1-mediated single-copy insertion method to increase production efficiency of transgenic strains of C. elegans.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042911-150135
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Year
  • 2011
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Date created
  • 2011-04-29
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Last modified
  • 2023-11-03

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