Faculty Advisor
Heilman, Destin
Faculty Advisor
Higgins, Lorraine D.
Sponsor
University of Massachusetts Medical School
Abstract
Vps45 is a Sec1/Munc18-like (SM) protein that regulates SNARE complex formation in endosomal vesicle fusion. In yeast, Vps45 has been shown to interact with its binding partner SNARE Tlg2, the yeast homolog of mammalian syntaxin 16 (Sx16), to control its entry into the SNARE complex. Recent studies have identified two independent single amino acid substitutions in Vps45 associated with the immune disorder severe congenital neutropenia. These results suggest that wild-type and mutant Vps45 interact comparably with the cytoplasmic portion of Sx16/Tlg2, but one mutant may associate less strongly with a truncation. Future research should further characterize the mutants using these binding assays. An online introductory guide to biomedical grant proposal writing was also created.
Publisher
Worcester Polytechnic Institute
Date Accepted
April 2017
Major
Interdisciplinary
Project Type
Major Qualifying Project
Copyright Statement
Access to this report is limited to members of the WPI community. Please contact a project advisor or their department to request access
Accessibility
Restricted-WPI community only
Advisor Department
Chemistry and Biochemistry
Advisor Department
Humanities and Arts
Advisor Program
Chemistry and Biochemistry
Advisor Program
Humanities and Arts
Your accessibility may vary due to other restrictions.