Faculty Advisor

Gibson, Daniel Gilbert

Abstract

We perfused neuromuscular transmitter (NMT) candidates through semi-intact legs of the horseshoe crab (Limulus polyphemus) during motor nerve stimulation, and measured claw closing strength. Glutamate and Aspartate enhanced, and GABA inhibited, contracture. But while the amino acids produced results typical of arthropod muscle, contractions were most strongly potentiated by eserine and inhibited by methyllycaconitine, which respectfully enhance and block Acetylcholine. We conclude that Acetylcholine, the vertebrate NMT, is also an endogenous excitor of Limulus muscle.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2004

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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