Faculty Advisor

Gericke, Arne

Center

SWITZ / Zurich Project Center

Abstract

Lidocaine, a local anesthetic was encapsulated into zein nanofibers through electrospinning. The impact of process parameters on electrospinning was studied in this project. Various concentrations of the active pharmaceutical ingredient (API), lidocaine, were successfully loaded into the nanofiber. The releasing behavior of the API was studied in vitro using PBS buffer followed by HPLC quantification, and in vivo by Skin Raman experiments. It was found that a fast and complete release of lidocaine from the nanofiber was achieved in PBS buffer (pH7.4) and released that lidocaine into the first 5 micrometer of human skin depth as followed by Raman experiments.

Publisher

Worcester Polytechnic Institute

Date Accepted

November 2018

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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