Student Work

Encapsulation of Lidocaine into Zein Nanofibers

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Lidocaine, a local anesthetic was encapsulated into zein nanofibers through electrospinning. The impact of process parameters on electrospinning was studied in this project. Various concentrations of the active pharmaceutical ingredient (API), lidocaine, were successfully loaded into the nanofiber. The releasing behavior of the API was studied in vitro using PBS buffer followed by HPLC quantification, and in vivo by Skin Raman experiments. It was found that a fast and complete release of lidocaine from the nanofiber was achieved in PBS buffer (pH7.4) and released that lidocaine into the first 5 micrometer of human skin depth as followed by Raman experiments.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-110118-220443
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Year
  • 2018
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Date created
  • 2018-11-01
Location
  • Worcester
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