Faculty Advisor

Gaudette, Glenn R.

Abstract

Lack of a viable vascular network impedes 3D bioprinting from creating functional tissues. Utilizing the native vasculature of decellularized spinach leaves as a scaffold for cell seeding provides the potential to form a viable vascular network. This network coupled with a gel matrix has the potential to provide the support and nutrients necessary for printing functioning tissues. Our data shows cell viability within a seeded scaffold after 36 hours and demonstrates cellular escape from the spinach leaf scaffold. When combined, the data shows that cells have the ability to adhere and escape from the scaffold, into a gel matrix, mimicking the initial steps for vascular growth.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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