Faculty Advisor

Gaudette, Glenn R.

Abstract

Electronic pacemakers are widely used to treat cardiac pacing problems, but the devices have inherent limitations. Hyperpolarization-activated cyclic nucleotide gated (HCN) transfected human mesenchymal stem cells (hMSCs) show promise as a solution to these problems, but these cells must be contained at the implant site to preserve functionality and patient safety. This project aims to design and fabricate a device that is capable of preventing cell migration while allowing for cell-cell interactions and enabling minimally invasive delivery. A heat-sealed, micropatterned scaffold was created to achieve mechanical strength and cell retention while maintaining low thickness necessary for cell interactions. Testing suggests cells can be safely restrained during and after implantation.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Share

COinS