Faculty Advisor

Page, Raymond L.

Faculty Advisor

Popovic, Marko B.

Abstract

1.7 billion people worldwide are affected by musculoskeletal conditions, and 90% of drugs fail phase 2 clinical trials due to lack of efficacy or unexpected muscular effects. Animal models and current 2D and 3D in vitro models aren’t accurate portrayals of in vivo human muscles. This project created a multi-well device to grow and mature 3D musculoskeletal tissues for drug testing and disease modeling by mechanically and electrically stimulating the tissues, simulating in vivo conditions. This design used microposts and air chambers with pumps to deflect the microposts, mechanically stimulating the tissue. It also used electrodes to electrically stimulate the tissue. The device was tested and shown that it had significant potential for successfully maturing 3D musculoskeletal tissue.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Interdisciplinary

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Advisor Department

Physics

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