MacDonald, John C.
Enantiomeric separation of racemic drugs is a never ending battle for pharmaceutical chemists. Conventional approaches to separating enantiomers (mirror-image stereoisomers) typically rely on chromatography utilizing chiral stationary phases or reactions of racemic drugs with chiral resolving reagents to form diastereomeric salts that crystallize separately. Separation of enantiomers by those techniques is often difficult and can add significantly to the cost of developing and marketing racemic drugs. The objective of this project was to develop a new surface-based approach to separating enantiomers of racemic drugs via selective crystallization on chiral surfaces consisting of gold substrates functionalized with self-assembled monolayers (SAMs) of a chiral organic compound.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry