Current treatments for Volumetric Muscle Loss (VML) defects limit the restoration of functional muscle tissue at the site of the wound, where the primary action and uniaxial growth of the myoblasts is destroyed. Wounded warriors and trauma patients undergo months of painful and expensive treatments for VML, with limited outcomes. Implantable biomimetic scaffolds are being explored as treatments for VML injuries because of their ability to guide uniaxial regeneration of muscle tissue. In this project, we created a reproducible, user friendly, and cost effective 3D model to depict skeletal muscle outgrowth onto fibrin microthreads in vitro, mimicking wound healing responses to the scaffold in vivo.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Heinle, Erin Elizabeth
• Morra, Emily Marler
• Mossman, Emily Margaret
• Paul, Alyssa M.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042519-100122

Advisor

• Whittington, Catherine Faye
• Pins, George D

Year

• 2019

Date created

• 2019-04-25

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright

Last modified

• 2021-02-01